Detaillierte Hinweise zur Behandlung von Opioidsucht

Detaillierte Hinweise zur Behandlung von Opioidsucht

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If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.

The dose conversion scheme below is derived from various consensus guidelines for converting chronic pain patients to methadone from morphine. Clinicians should consult published conversion guidelines to determine the equivalent morphine dose for patients converting from other opioids.

Since the metabolism of methadone is mediated primarily by CYP3A4 isozyme, coadministration of drugs that inhibit CYP3A4 activity may cause decreased clearance of methadone. The expected clinical results would Beryllium increased or prolonged opioid effects. Thus, methadone-treated patients coadministered strong inhibitors of CYP3A4, such as azole antifungal agents (e.

Methadone can Beryllium abused in a manner similar to other opioid agonists, legal or illicit. This should Beryllium considered when prescribing or dispensing methadone hydrochloride tablets hinein situations where the clinician is concerned about an increased risk of misuse, abuse, or diversion.

Hinein the selection of an initial dose of methadone hydrochloride tablets, attention should Beryllium given to the following:

Dispose of any unused methadone hydrochloride tablets remaining from a prescription as soon as they are no longer needed. Unused tablets should be flushed down the toilet.

Fertility – Reproductive function hinein human males may Beryllium decreased by methadone treatment. Reductions hinein ejaculate volume and seminal vesicle and prostate secretions have been reported hinein methadone-treated individuals. Hinein addition, reductions in serum testosterone levels and sperm motility, and abnormalities rein sperm morphology have been reported. Published animal studies provide additional data indicating that methadone treatment of males can alter reproductive function.

The complexities associated with methadone dosing can contribute to cases of iatrogenic overdose, particularly during treatment initiation and dose titration. A high degree of "opioid tolerance" does not eliminate the possibility of methadone overdose, iatrogenic or otherwise.

There may be new information. This leaflet does not take the place of talking with your doctor about your medical condition or your treatment. Share the important information rein this leaflet with members of your household.

Laxatives. Taking these drugs together can change your electrolyte levels. This can cause heart rhythm problems.

The intensity of the syndrome does not always correlate with the maternal dose or the duration of maternal exposure. The duration of the withdrawal signs may vary from a few days to weeks or even months. There is no consensus on the appropriate management of infant withdrawal.

Cimetidine. Taking this drug with methadone may cause increased drowsiness and slowed breathing. Your doctor might adjust your dosage of methadone, depending on how severe your side effects are.

You and your doctor should monitor certain health issues. This can help make sure you stay safe while you take this drug. Methadontabletten zur Schmerzbehandlung These issues include:

Methadone undergoes hepatic Nitrogenium-demethylation by cytochrome P-450 isoforms, principally CYP3A4, CYP2B6, CYP2C19, and to a lesser extent by CYP2C9 and CYP2D6. Coadministration of methadone with inducers of these enzymes may result rein more rapid methadone metabolism, and potentially, decreased effects of methadone. Conversely, administration with CYP inhibitors may reduce metabolism and potentiate methadone's effects. Pharmacokinetics of methadone may be unpredictable when coadministered with drugs that are known to both induce and inhibit CYP enzymes.